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Senescence: Reversing the Clock on Skin Aging

By: Shyam Gupta, PhD, and Linda Walker
Posted: April 4, 2012, from the April 2012 issue of GCI Magazine.

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Popular humectants such as sucrose, trehalose, maltose, cellobiose, gentiobiose, turanose and palatinose are very unusual osmoprotectants for the bacterium Sinorhizobium meliloti, because these compounds, unlike other bacterial osmoprotectants, do not accumulate as cytosolic osmolytes in salt-stressed S. meliloti cells. Rather, these compounds were catabolized during early exponential growth and contributed to enhance the cytosolic levels of the two endogenously synthesized osmolytes: glutamate and the dipeptide N-acetylglutaminylglutamine amide.17, 18 The dipeptide N-acetylglutaminylglutamine amide was discovered in the bacterium S. meliloti grown at high osmolarity, and subsequently shown to be synthesized and accumulated by osmotically challenged bacteria.19 Although the scientifically based and demonstrated information on senescence has become available, not to mention the ingredients technology to manage senescence, the development of practical consumer products targeted at controlling skin aging has eluded product developers. This is simply because there seems to be a historical lag period between a fundamental scientific discovery and its practical application.

Recent research has suggested the previously noted metabolite dipeptides may be useful for treating human skin aging.20 Both glutaminylglutamine amide and N-acetylglutaminylglutamine amide were found to have poor stability in typical water-based formulations. Fortunately, N-decanoyl-L-glutaminyl-L-glutamine amide, in its chirally correct21 molecular form, has shown excellent stability in aqueous-based systems. This discovery paves the way for the development of a new class of anti-aging skin care products based on preventing senescence, thus opening a new field for innovative marketing.

A large number of dipeptides and polypeptides are already known to provide skin anti-aging benefits. Although the relationship between cellular senescence antidotes in lower life forms to humans has not been established, the use of bacterial protection agents for human skin anti-aging—for example, the extracts of thermal tube worms and cyanobacteria—has precedence. The inclusion of N-decanoyl-L-glutaminyl-L-glutamine amide adds a new chapter to the arsenal of fight against human skin aging for a “forever younger” look. 

For a related discussion, please read New Solution for Anti-aging.

References

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  19. Sagot et al, Proc Natl Acad Sci USA, 107(28) 12652–12657 (2010)
  20. S Gupta and L Walker, U.S. Patent Application Publication 20110190202 (2010)
  21. SGupta and L Walker, Chiral Skin Care, GCI 178 11 44–46 (Nov 2010)