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The Future is Here

By: Sara Mason
Posted: March 3, 2010, from the March 2010 issue of GCI Magazine.

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Solar Vitis is the second of Mibelle’s ingredients to be based on the PhtyoCellTec technology, following the use of a rare Swiss apple variety used in skin care brand 3Lab’s collection of antiaging creams and serums that stimulate the skin’s own stem cells to combat wrinkles.

According to Mibelle, plant cell culture technology can, theoretically, be used to propagate any plants in the form of cells, opening many possibilities for the future. The company has other products based on this technology in the pipeline.

Cell-targeting Technologies

Cell-targeting technologies are already popular in marketed applications. Products based on lipopeptides, such as Sederma’s Idealift, fall into this category. They are designed to interact with specific target cells for specific activities, enhanced with homing structures that allow them to reach their targets, according to Lintner. Idealift stimulates the synthesis of elastin and other proteins related to its formation, acting on the skin fibroblasts involved in the building of elastic tissue. The company’s in vitro tests showed an increase of more than 94% in the settling of elastin/tropoelastin in the extracellular matrix after Idealift had been administered to the fibroblasts.

The possibilities are almost endless. “The more we understand cellular interactions—by molecular biology studies and other in vitro techniques—the more potential targets we find for these novel substances: stimulating repair enzymes, inhibiting breakdown processes, improving inter-cell communication, protecting DNA and other vital structures in the cells are all strategies that are being explored and applied,” explains Lintner. CoValence’s recent innovations—such as Mitoprotect, advanced spin trap technology, plant stem cell ingredients and chiral technology—provide a wide range of free radical scavenging, skin cell protection and nourishment and wide range skin beneficial functions as well. Mitoprotect technology was developed with encapsulated ingredients to nourish and stimulate the mitochondrial support enzymes. Mitoprotect 2 will be introduced soon, as a companion to the original Mitoprotect. It is formulated with a unique combination of mitochondria protect ingredients, featuring plant stem cells that have been created and produced by the company.

Private label company YG Laboratories, Inc., will introduce Cell Youth Serum as a stock or custom product this month (March 2010). It is a cell-targeted emulsion that utilizes technology ranging from stem cell stimulation to prolonging cellular activity and postponing senescence. Because tissues and proteins of the body are manufactured in the cell, the company focuses on working with DNA—looking at epigenetic influences, helping to elongate the lifespan of a stem cell before it goes into senescence. “We can help the cell remain healthy and active longer by supporting the different processes that the cell uses naturally to protect and repair DNA, at the mitochondria level,” says Rebecca James Gadberry, CEO, YG Labs. “By targeting the cell, we are able to bring the cell back into a much more youthfully active state, allowing the skin that it produces to be more youthful and have better quality in appearance, texture and clarity.” The basic premise is to stimulate the natural antioxidant enzymes in the cell, rather than sending antioxidants into the cell to do its work.

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