University of California, Davis (UC-Davis) researchers published a placebo-controlled clinical study on the benefits of Sytheon’s Synoxyl AZ (INCI: Acetyl Zingerone) in the Journal of Cosmetic Dermatology. Results show it can decrease wrinkles and other aging factors, as well as skin sensitivity.

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Sytheon collaborated with UC-Davis researchers on the double-blind, placebo-controlled, randomized clinical study. Results showed a significant decrease in: average wrinkle severity (p = 0.019; mean = 25.7% change); total wrinkle volume (p = 0.003; mean = 30.1 % change); pigment intensity (p = 0.021; mean = 25.6% change); and redness intensity (p = 0.035; mean = 20.7% change) in the Synoxyl AZ group after eight weeks of treatment, compared with the placebo.

As reported in the study, the acetyl zingerone was well-tolerated with daily use. No itching, burning or stinging was noted by study participants. Additionally, treatment with the ingredient maintained skin’s microbiome diversity with a > 20% increase in the skin-friendly Staphylococcus epidermidis.

As previously reported, Synoxyl AZ is a multifunctional ingredient that works as a moisturizer, antioxidant and selective chelator. The ingredient incorporates both proactive and reactive functionalities to provide protection and treatment of skin damage caused by continual exposure to the sun, pollution or blue light. Synoxyl AZ’s molecular structure is said to provide quick and long-lasting benefits by physically quenching and scavenging ROS with high efficiency, as compared with conventional antioxidants.

Reportedly, Synoxyl AZ is also more photochemically stable than many conventional antioxidants. The ingredient can be used in skin care formulations alone or in combination with conventional antioxidants to obtain a higher magnitude of benefits.

For more information, contact Sytheon.