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Section: Ingredients > Skin Care

Skin the needles: Perfectyl biofunctional from Ashland expands the Botox alternatives bringing new claims to topical beauty products.

Ashland's Perfectyl is a Needle-free Botox Alternative

The extract was developed using Zeta Fraction technology, which "gently separates live plants or algae into various bioactive components," per the supplier.

No needles necessary: Interest in Botox alternatives highlight consumers' desire for non-invasive (p)rejuvenation across age ranges, from Gen Z to boomers.

Argireline: Riding the 'Notox' Botox Alternative Wave

From viral products to novel ingredients, argireline is driving (p)rejuvenation innovation for consumers across the age spectrum.

Per in vitro testing, Myoline acts on the neuromuscular junction to impart a myorelaxing, or skeletal-muscle-relaxing, action. After five days of treatment with Myoline, the technology reportedly smooths the appearance of expression lines in young skin, while 'blurring' the appearance of wrinkles in mature skin.

Silab's Myoline Delivers a Relaxing Botox Effect

Myoline simultaneously stimulates the the oxytocin and endocannabinoid pathways of the skin to improve skin homeostasis. In fact, a volunteer study found that participants' perception of stress was reduced, while perception of skin health improved.

As Spate recently reported, younger consumers are increasingly exploring medical aesthetic procedures, as well as cosmetic products that offer similar results.

Lubrizol's Argireline YOUth Peptide Delivers Minimally Invasive, Botox-free Prejuvenation for Younger Consumers

In vivo results showed a minimized appearance of expression lines, without compromising the smile expression, as well as shorter and less visible wrinkles around the eyes, per Lubrizol.

Fewer trips to the medspa? Lubrizol's Argireline Amplified Peptide, when applied in combination with Botulinum toxin type-A injections like Botox, can 'keep wrinkles at bay for nearly 8 weeks longer than [the injections] alone.'

Lubrizol's Argireline Amplified Peptide Extends Botox-type Injection Results by 8 Weeks: New Study

Argireline Amplified Peptide, which is produced in accordance to green chemistry principles, has displayed "superior" in vitro activity and muscle relaxation effects compared to the company's original Argireline peptide.

Screenshot 20250411 121124 Editor Lite

12 Top Trends and Buzzwords in Beauty at In-Cosmetics 2025

Here's a quick rundown of the top trends in beauty ingredients and concepts we saw at In-Cosmetics Global 2025; and this is just a sampling.

Givaudan Active Beauty's Illuminyl 388 is an augmented green tea polyphenol (EGCG; epigallocatechin gallate) prebiotic skin brightening active with universal efficacy against skin pigmentation for all skin types.

Skin Pigmentation 2.0: May 2024 Beauty Trend Tracker

With hyperpigmentation concerns on the rise, ingredient suppliers have launched technologies to address issues related to acne, psoriasis and more.

From Silab’s Longevicell, which harnesses the rejuvenating power of myrtle leaves to target cellular mechanisms for longevity, to Evolved By Nature's Activated Silk KDF-β peptide, designed to combat modern environmental stressors, these advancements are setting new standards in skin care ingredients.

Revolutionizing Skin Care: Innovative Ingredients Transforming Anti-Aging and Skin Health

Exploring the science, benefits, and sustainability behind these advanced ingredients, offering a closer look at how they address key skin concerns like aging, oxidative stress, and damage repair.

The 'beautyspan' refers to the duration of one’s skin and hair health/wellness, centering the discussion on holistic, preventive and regenerative strategies, rather than solely aesthetic solutions.

The Beautyspan: Biohacking Longevity (Ingredient Trend Tracker)

“Today’s longevity-boosting ingredients are designed to tackle the root causes of aging at a cellular level.”

The connection between diet and the skin has long been known, but new research points to the connections between skin and gut health for a range of issues, including acne, atopic dermatitis, eczema and psoriasis.

Gut Health as Skin Health: Ingredient Trend Tracker

Holistic wellness trends and emerging science are intersecting, providing new innovation targets for beauty products and claims.

Current scientific literature points to “growing evidence that cellular senescence may be an essential mechanism that drives organismal aging,” including in the skin, leading to common issues such as “wrinkling, sagging, dryness or age spots.”

Beauty’s War on Senescence: Ingredient Trend Tracker

Regenerative technologies that clear the skin of zombie cells are reshaping beauty claims possibilities. PLUS: in-cosmetics Global 2024 ingredient highlights.

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