Provital LLC
Provital has dedicated more than 40 years to discovering the treasures that nature provides, mainly from vegetal sources, from all around the world. We thoroughly study their application to skin and hair care and develop high-quality, efficacious cosmetic ingredients combining the best from nature and science. To this end, we boast two main product lines:
- CareActives™ harnesses the power of science and nature working together to promote well-being with 67 active ingredients proven to be effective in enhancing natural beauty.
- CareMotives™ captures the essence of nature with 290 ingredients of natural origin, to awaken the emotions evoked by innate beauty.
We believe that taking care is taking action.
At Provital, our dedication to nurturing beauty allows us to create natural active ingredients that evoke positive emotions and provide individuals with the means to express their own unique beauty. We bring exceptional customer care to the beauty industry and beyond, reflecting our unwavering dedication to excellence in both our product and the services we provide. And because we are conscious that each of our clients has specific needs, we co-create with them, always working collaboratively, anticipating trends, and leveraging those trends into helpful formulations.
Our approach: combine nature + science
Our approach emphasizes creativity, inspiration, and cutting-edge science in everything we do. We develop sustainable, plant-based biotechnology platforms, including Plant Stem Cells, Microalgae, and Endophytes. Our state-of-the-art In Vitro laboratory enables us to conduct high-level scientific research from inception to completion, and our award-winning ingredients attest to our commitment to excellence. At Provital, we make sure we use technological breakthroughs to improve the quality of active ingredients and extracts that are incorporated in the current cosmetic market. We have also worked to ensure we have the right bioinformatic capacities for the analysis of massive data. This is where our Provital’s Bioimage and Bioinformatic Platform (PBBP) comes in. Through this platform, we can obtain a data-driven approach that guides us to perform better cosmetic ingredient evaluations. This translates into several benefits:
- Utilize our tissue engineering expertise to perform novel studies.
- Access high-content imaging, as well as having access to enhanced image analysis that extracts valuable information from great volumes of data.
- Uncover new mechanisms of action.
Global presence
Headquartered in Barcelona, Spain, we are a leader in the cosmetics industry, present in over 114 countries, and with subsidiaries in key markets worldwide including Brazil, China, France, Poland, Germany, and most recently, the USA.
Do Care
Caring is at the heart of everything we do. It is what drives us to continuously innovate and create products that make a positive impact on people and the environment. Do Care is not just a tagline; it's a reflection of our commitment to making a difference.
In today’s hyper-choice era, beauty consumers face an avalanche of launches, ingredients and efficacy claims, and abundance is turning into frustration. Nowhere is this clearer than in well-aging, an ingredient-driven category built on hero molecules, where retinol remains the undisputed benchmark for wrinkle reduction and texture improvement. Yet its efficacy comes with irritation, sensitivity and increasingly restrictive regulation.As the market floods with “retinol alternatives”, consumers look for selective, tolerable and naturally sourced solutions. Meanwhile, Traditional Chinese Medicine resurges as a longevity-oriented wellness language, with “Chinese chic healthcare” mentions up 427% on social media between 2022 and 2024. Differentiation no longer means replicating retinol, but delivering only its positive side through a targeted mechanism, and a natural and attractive storytelling.Provital answers with Retilance™, a next-generation active that elevates retinol science for multidimensional radiance. Built on the 3S-Retinol concept (Selective well-aging, Safer option, natural Source), it does not simply replicate retinol claims: it reframes them through a more selective, safe and consumer-compatible approach to skin longevity.Retilance™ is an extract of the root of Atractylodes lancea, an herb long used in Traditional Chinese Medicine for body balance and vitality, standardized in total polyphenols. Screened among plant extracts for RARα agonist activity, it emerged as the most active candidate. Able to modulate RAR signaling without eliciting the full spectrum of retinol responses, it reproduces the beneficial side of retinoid biology while sparing the pathway linked to irritation: multidimensional radiance, from receptor to skin surface.Whole-transcriptome sequencing in human dermal fibroblasts revealed that Retilance™ shares ~80% of the transcriptomic signature of retinol (5,342 genes regulated in the same direction), activates RAR signaling and up-regulates key RAR-mediated pathways associated with skin renewal and matrix regeneration, while avoiding the activation of an important irritation-related pathway (TRPV1). This targeted modulation translates into a selective retinoid-like modulation of skin regeneration, antioxidant defense, extracellular matrix remodeling, and structural cohesion. In fact, Retilance™ promotes a superior expression in genes most related to collagen synthesis (vs retinol).Backed by advanced in vitro and in vivo research, Retilance™ rethinks what superiority means in today’s hyper-choice era, through the three dimensions consumers now expect from modern well-aging products:Selective efficacy: by activating RAR, inducing retinoid metabolism, and replicating 80% of retinol’s transcriptomic footprint in fibroblasts, Retilance™ strengthens skin structure, and delivers a healthier skin texture that looks (and feels) younger.Safer Option: besides not activating key TRPV1-mediated irritation pathways in vitro, Retilance™ demonstrated excellent skin tolerability in vivo, even on sensitive skin.Natural Source: due to its connection with Traditional Chinese Medicine (TCM), Retilance™ embodies a holistic and balanced approach to skin longevity,Two randomized, double-blind, genderless studies on 113 volunteers (51 vs placebo - across Europe, Africa and Asia, 30% with sensitive skin - plus 62 Asian women vs retinol), measured by instrumental analysis, showed that 2% Retilance™ visibly improved firmness, elasticity, texture, wrinkle depth, radiance and hydration vs placebo, with significant effects from day 14 on structural parameters and no adverse reactions. Versus 0.3% retinol, it achieved comparable anti-aging efficacy and a significant 10% more on skin radiance.Retilance™ stands as a 100% natural origin (ISO 16128), Halal certified, China and Vegan compliant ingredient that, by reframing retinol claims through selective, safe and natural efficacy, outshines the hero to enable premium well-aging positioning for sensitive-skin, holistic and TCM-inspired formats.In a market overwhelmed by choice, Retilance™ elevates product differentiation through its triple-hero superiority and its multidimensional benefits on every skin type and tone.
- Cosmetic Ingredients(AHA, Acne Treatment, Anti-acne, Anti-aging, Anti-inflammatory, Anti-irritant, Anti-pollution, Anti-wrinkle, Antibacterial, Antidandruff and more)
