Silab’s Longevicell Targets Sirtuins, Co-activators for Anti-aging, Longevity Efficacy

Silab Longevicell (1)
Silab

Silab delivers on consumer demand for natural and proven anti-aging products with Longevicell, an active ingredient that leverages the oligogalacturonans present in myrtle leaves. The ingredient reportedly targets sirtuins and their coactivators — NAD+ and AMPK — to support cellular longevity and promote youthful, radiant skin.

Targeting Cellular Mechanisms for Longevity

As Silab explains, sirtuins play a central role in promoting healthy cell functioning but their activity relies on the availability of NAD+ (essential for mitochondrial energy production) and AMPK (an energy sensor that protects cellular metabolism). Longevicell (INCI: Water (Aqua) (and) Hydrolyzed Myrtus Communis Leaf Extract) activates sirtuins 1, 3, 6 and 7, as well as NAD+ and AMPK, boosting mitochondrial activity and mitigating cellular aging processes like glycation and senescence. By acting on these key mechanisms, the ingredient reduces protein oxidation and increases cellular energy production at the epidermal level, enhancing skin's complexion and radiance, according to Silab.

Proven Skin Benefits in 14 Days

Internal studies showed Longevicell enhanced protein oxidation repair and increased cellular energy production in the epidermis while improving dermal matrix quality. These biological improvements translated to visible skin benefits in as little as 14 days.

More specifically, in Caucasian and Asian skin, after 14 days of application, the ingredient noticeably improved:

  • smoothness (in body skin) and
  • radiance (in facial skin).

After 28 days, additional benefits emerged:

  • greater skin elasticity,
  • firmness and
  • reduced wrinkles.

Feedback from study participants also supported these findings, with 100% of Caucasian subjects reporting smoother and more radiant skin, and 95% identifying Longevicell as an effective anti-wrinkle treatment, Silab reports.

Ancient Myrtle, Modern Benefits

Longevicell is grounded in the history and sustainability of myrtle. The shrub has been treasured since antiquity for its rejuvenating properties, per Silab, and was traditionally used to prepare “angel’s water” for enhancing skin freshness.

Today, Silab sources myrtle leaves from certified organic suppliers in Morocco, ensuring quality and adhering to sustainability standards. The ingredient's production is traceable, from harvest to finished ingredient, to comply with biodiversity and regulatory requirements.

Ingredient Properties, Formulating Benefits

Longevicell is 99.3% naturally derived or higher (per ISO 16128), and suitable for face and body formulations at 1% to 4%. It is available in an aqueous format, and is compliant with global cosmetic regulations.

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