An uneven skin tone refers to the heterogeneous distribution of not only a single-colored molecule, but also the combination of various brown, black and gray colored complexes, each of which can develop the individual skin color tone.
Whereas the presence of Advanced Glycation End-products (AGEs) by themselves is responsible for the development of brown skin tone, AGEs may mediate signal transduction by binding to receptors for AGEs (or RAGEs) for the development of black and gray tones via the production of melanin by melanocytes and suppression of keratinocyte differentiation, respectively.
Therefore, the inhibition of AGEs production and their subsequent signaling pathways could hold the key to comprehensively achieving an evenness of all colored skin tones.
ICHIMARU PHARCOS proposes three natural cosmetic ingredients that resolve uneven skin tone.
1. Peoglow: PeoGlow improves skin tone unevenness by inhibiting the binding of AGEs to RAGE, which can be the origin of brown, black and dark grey tones. PeoGlow provides a fundamental approach to improving overall uneven skin tone and achieving radiant, glowing, beautiful skin.
Benefits of PeoGlow include:
- Reduction of uneven skin tone,
- Reduction of AGEs,
- Stopping AGEs-RAGE signaling and
- Reduction of age spots.
2. Absorage: Absorage is an anti-glycation ingredient that prevents protein glycation and the loss of skin transparency, and skin aging (wrinkles, reduced flexibility, etc.).
Benefits of Absorage include:
- Prevention of skin browning,
- Reduction of AGEs and
- Reduction of wrinkles.
3. JuniperBright: Lipofuscin that accumulates in cells with age reduces skin transparency by blocking light transmission, causing skin dullness. We focused on both proteasome and autophagy, the intracellular purification systems, to develop JuniperBright, which increases their activities and suppresses the accumulation of lipofuscin in human epidermal keratinocytes.
Effects of JuniperBright include:
- Reduction of lipofuscin accumulation (through activation of proteasome and autophagy),
- Skin brightening,
- Increase of internal reflected light and
- Reduction of skin age spots.
One of our JuniperBright researchers published an article on the innovation in Biochemistry and Biophysics Reports.
Please contact us for samples and further information.
About ICHIMARU PHARCOS
We, ICHIMARU PHARCOS, are a company in Japan having more than 60 years of history in the research and development of cosmetic active ingredients obtained from natural resources. Our products are highly valued by both world-class cosmetic companies and local cosmetic manufacturers. Not only do we distribute our natural ingredients, we also innovate to support the latest cosmetic trends, develop intellectual properties and comply with global cosmetic laws.
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