During NYSCC Suppliers' Day, held June 3 and 4, 2025, in New York City, MetaNovas Biotech presented its AI-driven peptide portfolio. In addition to three previously described ingredients — MetaTlr, MetaScalp and MetaCono, for anti-inflammation and skin balance, anti-dandruff and anti-wrinkle activities, respectively — the company highlighted four innovations demonstrating advances in microbial harmony, cellular senescence, oral microbiome regulation and inflammation control.
ClearAcne Magic for Acne Relief, Microbial Balance
ClearAcne Magic (INCI: Not Provided) is designed to restore microbial harmony in acne-prone skin to effectively support the prevention of blemishes. More specifically, the ingredient regulates sebaceous gland activity and inhibits Cutibacterium acnes.
In addition, it prevents NO production and IL-6 and IL-1β activation, thereby reducing inflammation. According to the company, the precise microbial management provides a non-irritating solution, making ClearAcne Magic suitable for sensitive skin.
OmniYouth Peptide for Youthful Skin Appearance
Inspired by senomorphic and senolytic science, OmniYouth (INCI: Not Provided) is said to tackle signs of aging at the cellular level. This rejuvenating peptide targets senescent cells, which are often key contributors to age-related skin concerns such as reduced elasticity and UV-induced damage.
Mechanisms of Action
Per the company, the ingredient acts by:
- Decreasing the expression of inflammatory factor NF-κB,
- Inhibiting microbial lipopolysaccharides (LPS) that cause skin irritation,
- Neutralizing ROS to prevent damage caused by oxidative stress,
- Repairing and reducing UV-induced skin damage, reducing inflammation and cellular damage, while also increasing the expression levels of LMNB1 and COL 1A 1, and
- Inhibiting cellular senescence, as demonstrated through a reduction in senescence-associated β-galactosidase.
According to in vitro studies, OmniYouth's demonstrated effects make it an excellent addition to formulations aimed at anti-aging and daily skin repair.
PureSmile Peptide for Oral Microbiome Regulation
PureSmile addresses a lesser-explored frontier in cosmetic solutions — oral health. The peptide is designed to regulate the oral microbiome, paving the way for a healthier smile.
In particular, the ingredient targets microbial dysbiosis by selectively inhibiting the gingival pathogens Streptococcus mutans and Porphyromonas gingivalis, as well as Helicobacter pylori, a bacterium linked to gastric disorders. What's more, it inhibits NO production, exerting an anti-inflammatory effect.
According to the company, this innovation carries implications not just for maintaining fresh breath, but also for oral hygiene support in broader personal care contexts. Including this ingredient in oral care formulations thus enables a more holistic approach to personal wellness.
IntimateGuard for Gentle, Effective Vaginal Care
Finally, designed for intimate personal care, IntimateGuard offers antibacterial and anti-inflammation effects specifically for the delicate vaginal area. The ingredient reportedly can selectively absorb and destroy harmful bacteria such as Escherichia coli, Staphylococcus aureus and Candida albicans without causing resistance.
Through its gentle mechanism of action, IntimateGuard also reduces inflammation without compromising the natural protective barrier of sensitive skin. In addition, according to the company, it does not inhibit probiotics and preserves the integrity of beneficial vaginal microbiota, such as Lactobacillus acidophilus.
This ingredient is said to strike a balance between efficacy and sensitivity, providing formulators with an option for intimate care products addressing discomfort, irritation and overall skin health.
