DSM-Firmenich's Eterwell Youth (INCI: Epilobium fleischeri leaf/stem extract), a senolytic skin care technology derived from Alpine willowherb, has won the awar for Best Active Ingredient Award in Skin Care by in-cosmetics Global.
The technology reduces the number of excess senescent cells in the epidermis and dermis (per in vitro and ex-vivo tests), thereby dropping senescent markers such as p16 and p21 (as illustrated ex vivo, per the company).
As a result, IL-1, which is thought to be involved in inflammaging, is reduced with use of Eterwell Youth (in vitro). Other senescent-associated secretory phenotypes (SASP) are also reportedly diminished.
Furthermore, senescent cells are replaced with high-performing cells that boost collagen by 44% (ex vivo with 1% Eterwell Youth).
According to DSM-Firmenich, 3% of Eterwell Youth applied for 2 weeks boosts skin smoothness by 24%, "corresponding to a skin physiological age looking 2 years younger and even 6 years younger after 3 months."
The same concentration of the ingredient also cuts crows feet wrinkle volume by 17% and depth by 11% within 3 months.
DSM-Firmenich adds that Eterwell Youth has a synergistic effect when formulated in conjunction with technologies such as TGF-b and retinol.
The ingredient is COSMOS approved, Natrue organic and Fair for Life fair trade certified.
The extract is sourced from rare Alpine willowherb that is organically cultivated in a Swiss ancient glacier moraine.
