Givaudan Active Beauty recently launched a new product: PrimalHyal UltraReverse. According to the company, the product is the smallest and most sustainable hyaluronic acid developed to date, capable of penetrating skin cells at the DNA level to tackle the primary hallmarks of aging. PrimalHyal UltraReverse specifically targets four critical pathways: epigenetic control, genomic instability, telomere attrition, and loss of proteostasis. By addressing these biological processes, the ingredient can combat chronological aging and protect skin from environmental stressors, known collectively as the exposome.
PrimalHyal UltraReverse was reportedly designed to address four of the five key hallmarks of aging:
- Epigenetic Control: Restores DNA methylation processes while enhancing Sirtuin expression and activity, reducing cryptic transcription.
- Genomic Instability: Strengthens DNA repair mechanisms to promote healthier, more resilient skin.
- Telomere Attrition: Reactivates telomerase expression and activity, preserving chromosome integrity and cellular longevity.
- Loss of Proteostasis: Enhances proteasome activity to maintain optimal cellular function and balance.
According to Giavaudan, PrimalHyal UltraReverse has shown impressive results, including an increase in sirtuin 1 by 136% and collagen 1 production by 48%, which can contribute to reduced signs of aging. The ingredient was designed for its ultra-low molecular weight, achieved through advanced precision fermentation, which also reduces its environmental impact.
Romain Reynaud, research & development director, Giavaudan says, "Building on the expertise of PrimalHyal 50 Life, strain engineering experts at Alderys have designed PrimalHyal UltraReverse, an ultra-low molecular weight hyaluronic acid, lower than 3 kDa, that unlocks new biological benefits. Produced by precision fermentation, its environmental impact is drastically reduced—setting a new benchmark for sustainable, high-performance skincare."
