Happy Aging Pairs Science and Wellness to Boost Skin and General Longevity

Happy Aging Longevity Shots bottles and box
The ingestible Happy Aging NAD+ Longevity Shot ($60/10 units) delivers a rejuvenating beauty-from-within benefit via nicotinamide riboside, a form of vitamin B3 that boosts the body's own production of NAD+, which revitalizes aging cells and improves cellular metabolism for a refreshed, more energized skin.
Happy Aging

Happy Aging is taking on skin longevity and pro-aging with a new ingestible, the NAD+ Longevity Shot, and a diagnostic solution, a biological age test.

The brand was founded by entrepreneur and wellness influencer, Martha Graeff, and longevity expert Daniel Yadegar, MD, FACC, RPVI.

Happy Aging NAD+ Longevity Shot: Regenerative Skin Care

The ingestible Happy Aging NAD+ Longevity Shot ($60/10 units) delivers a rejuvenating beauty-from-within benefit via nicotinamide riboside, a form of vitamin B3 that boosts the body's own production of NAD+, which revitalizes aging cells and improves cellular metabolism for a refreshed, more energized skin.

As previously reported, NAD+, or nicotinamide adenine dinucleotide, targets multiple pathways, including attenuating mitochondrial alterations, DNA damage and oxidative stress by modulating such enzymes as sirtuins, glyceraldehyde-3-phosphate dehydrogenase and AP endonuclease. These activities suggest the therapeutic and nutritional potential of NAD+ for addressing senescence and more.

Beyond nicotinamide riboside, the Happy Aging NAD+ Longevity Shot includes:

  • antioxidant resveratrol to boost cellular detoxification and skin firmness
  • antioxidant alcohol-free red wine powder
  • antioxidant and brightening blood orange extract
  • detoxifying spinach leaf juice powder for a stronger skin structure
  • antioxidant grapeseed extract to diminish the appearance of dark spots
  • barrier reinforcing ceramides for improved skin elasticity

The shot features a mixed berry flavor and reportedly accrued a 10,000-person waitlist prior to the brand's launch.

In addition to the shot, Happy Aging has partnered with TruDiagnostic to develop the Happy Aging Biological Age Test.

The system analyzes more than 75 biomarkers to measure biological age, speed of aging and the health of 11 organ systems.

The test results are offered via three main aging outputs:

  • DunedinPACE, "a novel blood biomarker of the pace of aging for gerontology and geroscience"
  • OMICmAge, "an integrative multi-omics approach to quantify biological age." OMICmAge was developed by TruDiagnostic in partnership with Harvard University and examines proteins, metabolites and clinical biomarkers to provide a picture of how the body is aging. 
  • SYMPHONYAge (System Methylation Proxy of Heterogeneous Organ Years), which is exclusively licensed from Yale University and "provides a new way of looking at aging by examining how different parts of the body decline independently, and synchronously, over time." Per Happy Aging, SYMPHONYAge    looks at how organ systems such as the brain, liver, heart and immune system age both independently and in sync with one another. 

Per Happy Aging, the diagonostic reports will include personalized data from all three aging outputs, plus general lifestyle recommendations to support continued wellness. The tests are available online for $499.

A Positive, Cellular-level View of Aging

"Aging is a journey we all experience, but it shouldn't be something we fear," says Graeff. "With Happy Aging, we're empowering women to take control of their health, feel vibrant, and embrace every stage of life with confidence. Our goal is to shift the narrative around aging and show that it's possible to age in a way that feels good, both inside and out."

"Happy Aging is bridging the gap between cutting-edge science and everyday wellness to provide consumers with the agency they need," says Yadegar. "The Biological Age Test offers a deep look into how our bodies are aging at the cellular level. With the Longevity Shot, Happy Aging has combined years of research into a simple, yet powerful routine."


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